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vascular health

Full-spectrum tocotrienol-tocopherol complex effective for vascular health

Single, pure tocotrienol isoforms are not as effective as the natural full spectrum palm tocotrienol/tocopherol complex, EVNol (previously known as Tocomin) in reducing oxidative stress and restoring endothelium-dependent relaxation in a newly published study, conducted at the Royal Melbourne Institute of Technology University (RMIT), Australia. The study also highlights that the presence of alpha-tocopherol is essential for tocotrienols to exert this restoration for vascular health.

Abnormal endothelial cell function (endothelial dysfunction) is a sign of various vascular diseases and importantly, an early marker in the development of atherosclerosis and where there is disease-induced oxidative stress such as diabetes and hypertension.

This study set out to compare antioxidant activity of individual tocotrienol isoforms (alpha, gamma, and delta), alpha-tocopherol, and EVNol. EVNol is a natural, full-spectrum tocotrienol-tocopherol complex derived from red palm oil, consisting of approximately 78% tocotrienols and 22% alpha-tocopherol. In addition, the study investigated the potency of these various vitamin E groups in preserving endothelial function during oxidative stress.

The researchers found that all individual tocotrienol forms (alpha, gamma, delta) effectively scavenged superoxide, but did not improve endothelial function unless alpha-tocopherol is present. Alpha-tocopherol and alpha, gamma, and delta tocotrienols were able to reduce oxidative stress at concentrations as low as 10-3 mg/ml, whereas EVNol was able to achieve the same effect at much lower concentrations – as low as 10-5 mg/ml. EVNol is more potent than alpha-tocopherol at restoring endothelial function since the effectiveness of EVNol begins at 100 times lower concentration than that of alpha-tocopherol.

The capacity of EVNol to preserve endothelium-dependent relaxation was attributed to its rapid elimination of superoxide, as has been previously reported with superoxide dismutase preservation of relaxation in the presence of oxidative stress.

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“This is an exciting study that provides new evidence showing that alpha-tocopherol plays an important role in preserving endothelial function by itself as well as in an increased synergy with the tocotrienols. The natural complex of tocotrienols and alpha-tocopherol in EVNol function synergistically to prevent oxidative stress and restore endothelial function at a very low concentration. Approximately 100 times more potent than alpha-tocopherol alone,” says WH Leong, CEO of ExcelVite Inc.

“There are 8 isoforms of vitamin E in nature, and all vitamin E forms exist for important reasons as nature knows best that for vascular protection, both tocotrienols and tocopherols work together synergistically to confer a higher beneficial effect. This also reflects recent European research studies that show high blood levels of all vitamin E forms (mixed tocopherols and mixed tocotrienols) protect elderly people from the risk of mild cognitive impairment and Alzheimer’s disease,” added Leong.

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