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Clinical study shows benefits of tocotrienol-infused facial masks

ExcelVite, the leading and only GMP-certified tocotrienol and palm mixed-carotene producer, shared the results of an in-vitro and human efficacy study of facial gel mask infused with palm tocotrienol complex (EVNol) in conferring facial skin moisturizing benefit.

Among the many skin care product categories, the market for facial masks is still considerably small compared to the overall global skin care sales. However, in the United States and some European countries such as UK, Italy and Spain, facial mask sales are on the increase. In fact, sales of facial masks in the U.S. experienced a significant 60 percent rise to $65.5 million between July 2013 and June 2014, according to market research firm NPD. The main consumer of facial masks is China, where the 2014 market size was estimated at $1.6 billion and growing at an average 30 percent rate annually, according to a report from HAPPI China.

Researchers from the Malaysian Palm Oil Board (MPOB) developed a formulation of a facial gel mask infused with palm mixed tocotrienol complex (EVNol), a high-performance vitamin E.  Upon contact, the gel hydrates and seals the moisture in the skin. And at the same time, it enables transdermal delivery of tocotrienols.

In order to study the efficacy of the gel mask, MPOB researchers first tested the EVNol-infused gel for irritancy potential using an in-vitro irritancy assay kit. Then they conducted an in-vivo patch test on 20 human volunteers. Both in-vivo and in-vitro studies showed that the EVNol-infused gel was non-irritating to human skin.

Next, they went on to study the moisturizing effect of the EVNol-infused gel mask, comparing it to a placebo and a commercial mask against untreated skin areas on 20 human volunteers. The masks were applied for 30 minutes and then removed. Skin hydration levels were measured at different intervals up to 180 minutes. At 180 minutes past gel mask removal, significant differences were observed in skin hydration levels among the mask samples studied. The EVNol-infused gel mask demonstrated the most significant hydration benefits by maintaining about 50 percent of skin moisture compared to the untreated area. Just as important, the gel mask without inclusion of actives (placebo) showed significant moisture loss 30 minutes after mask removal.

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Another in-vitro skin permeation study was conducted to assess skin permeability and antioxidant activity of the EVNol-infused gel over different intervals. The permeate fluids collected from the study were found to contain tocotrienols and exhibited potent antioxidant activity from DPPH-scavenging test.

The researchers concluded that the gel mask formulated with palm mixed-tocotrienol complex (EVNol) is a non-irritant to skin, able to maintain skin moisture levels and at the same time, able to enrich the skin with antioxidants.

“This MPOB study shows that EVNol high-performance vitamin E-infused masks are not a skin irritant and provide immediate skin moisturizing effect that lasted longer compared to other commercial masks. In a study by Maret Traber, et al. that evaluated the tissue-specific distribution of lipophilic antioxidants, it was found that nearly 15 percent of tocotrienols (compared to 1 percent of tocopherol) were distributed to the skin (preferential accumulation of tocotrienols in the skin), hence it is conceivable that facial gel mask embedded with EVNol will be able to deliver tocotrienol to the skin to confer skin health benefits as shown in this MPOB study and other studies in the past,” said ExcelVite Regional Product Manager Bryan See.

“In view of increased consumer acceptance and expectations on facial mask to improve facial skin health and beauty, it provides a significant market potential and as such, now is the right time for companies to consider formulating facial masks with EVNol palm tocotrienol complex which are effective and environmentally friendly that also comes with a sustainability message as an added marketing advantage and differentiation,” added See.

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