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Metabolic syndrome trial helps refine palm tocotrienols intake levels

A randomized, double-blind, cross-over and placebo-controlled clinical trial shows that in subjects with metabolic syndrome, supplementation with 400 mg palm tocotrienol complex for 14 days is well-tolerated, with no signs of any adverse health events of blood profile (haematoxicity) and liver functions (hepatotoxicity). These results may help the scientific community establish intake recommendations for tocotrienols, particularly the tolerable upper intake levels.

In this study, 31 subjects with metabolic syndrome, ages 25 to 56 years old, were randomized to receive either 400 mg of palm tocotrienol complex (EVNol SupraBio, supplied by ExcelVite) or placebo for 14 days. This was followed by measurement of body weight, haematological profile (physiology of the blood) and liver functions examination. When compared to placebo, subjects supplemented with EVNol SupraBio (a patented bio-enhanced natural full spectrum palm tocotrienol complex) demonstrated no negative effects on red blood cells, white blood cells and platelet counts. Additionally, patients under EVNol SupraBio treatment did not show significant differences in body weight, and serum liver enzymes such as aspartate aminotransferase, alanine aminotransferase and albumin. Collectively, EVNol SupraBio is well tolerated with no toxicity issue such as weight loss, bleeding tendency or interference with the haemostasis status. In addition, EVNol SupraBio does not affect liver function nor increase the risk of hepatotoxicity.  

“Apart from this study, another recent clinical study also reveals that daily supplementation of 400 mg of d-mixed tocotrienol (EVNol SupraBio) for 52 weeks demonstrates fatty liver amelioration in non-alcoholic-induced fatty liver subjects, without any reported adverse health effects1. Fatty liver is the precursor to metabolic syndrome (e.g., diabetes, obesity and hypertension) and these encouraging clinical results allow companies to formulate a liver health product with EVNol SupraBio to address fatty liver,” says CheeYen Lau, ExcelVite nutritionist.

“Not all tocotrienol are created equal. In fact, EVNol SupraBio, manufactured by ExcelVite, is the only GMP-certified tocotrienol complex in the world. EVNol SupraBio has been used in more than 15 human clinical studies for different endpoints and health benefits such as brain protection, cardiovascular health (e.g., healthy cholesterol level and arterial compliance), liver health as well as skin and hair growth. This is the first human clinical study that evaluates the safety of tocotrienol in terms of haematological and hepatological profiles vis a vis proven safety results of EVNol SupraBio,” added Lau.


  1. Magosso E, et al. (2013, Dec 27). Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial . Nutr J., 12(1), 166.
  2. Lin, G.Y., (2016). Safety Assessment of Tocotrienol Supplementation in Subjects with Metabolic Syndrome: A Randomized Control Trial. Journal of Oil Palm Research; Vol.28 (1) March 2016p.34-43.
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