A newly published preliminary animal study conducted by Monash University researchers shows that EVNol SupraBio patented and bio-enhanced natural full-spectrum palm tocotrienol complex may have beneficial effects in ameliorating several metabolic syndrome-related conditions after four weeks of supplementation.

Researchers at Monash University conducted this study on 21 rats randomized equally into three groups: control diet, high-fat diet and tocotrienol-rich fraction (TRF). The control diet group was given a low-fat diet, while the high-fat diet and TRF groups were given high-fat diets for eight weeks to induce metabolic syndrome. Subsequently, for four weeks the TRF group was supplemented with 60mg/kg of tocotrienol-rich fraction of palm oil (Tocovid SupraBio full spectrum palm tocotrienol complex which contains ExcelVite’s EVNol SupraBio), delivered in a 10 percent glucose solution. The control and high-fat diet groups were given just the 10 percent glucose solution for four weeks. At the end of the experiment, the rats underwent a 12-hour fast prior to euthanasia with carbon dioxide. Blood and tissue samples were collected, processed and analyzed.

The researchers found that eight weeks of a high-fat diet induced full-blown metabolic syndrome in the rats, including diabetes mellitus. Subsequent four weeks of TRF supplementation was able to:

  1. Reverse hypertension, hypercholesterolemia and fatty liver.
  2. Inhibit protein glycation to reduce glycated haemoglobin A1c and advanced glycation end products.
  3. Restore antioxidant capacity and reduce myeloperoxidase activities that may lead to oxidative stress.

On the other hand, the researchers did not observe significant results in relation to visceral fat deposits, glucose level, plasma triglycerides or peroxisome proliferator-activated alpha and gamma expression.

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Based on these favorable findings, the researchers concluded that TRF may have potential for metabolic syndrome therapy especially on cardiovascular and liver health, and therefore is worth further investigation.

ExcelVite Business Development Manager Bryan See explains, “In addition to the potent antioxidant property of tocotrienol which plays an important role in restoring antioxidant capacity and attenuating oxidative stress in metabolic syndrome condition, this study provides exciting results that for the first time, reveal the suppression of glycation by EVNol SupraBio bioenhanced full-spectrum palm tocotrienol complex, which may reduce glycated haemoglobin and AGE in the liver.”

See added, “We are absolutely delighted with this new finding and research development in metabolic syndrome, as it mirrors the findings of our earlier human studies that show EVNol SupraBio bio-enhanced palm tocotrienol complex is beneficial for maintaining healthy cholesterol level, supporting healthy blood pressure and improving fatty liver that collectively may reduce the risk for metabolic syndrome condition.”

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