The effectiveness of EVNol natural full-spectrum palm tocotrienol complex as a neuroprotective and antioxidant agent in chronic cerebral hypoperfusion-induced neurodegeneration was recently demonstrated by a group of researchers from Faculty of Medicine, International Islamic University Malaysia and Menoufia Medical School, Egypt.

A 2-vessel occlusion (2VO) rat has neuronal cell death in the hippocampus and cerebral cortex, which are the same structures affected during progressive neurodegeneration in Alzheimer’s patients. In this study, 24 Sprague Dawley rats were equally divided into three groups: (i) control (placebo surgery), (ii) 2VO model (untreated), and (iii) 2VO+E model (treated). The 2VO+E model is a group of rats supplemented with 100 mg/kg palm tocotrienol mixture (EVNol, supplied by ExcelVite) for 8 weeks.

Histopathological examination in the hippocampus region reveals that the neuronal cells in the group of rats receiving EVNol (2VO+E) group showed similar characteristics as in the control group. There is also less neuronal cell damage in group of rats receiving EVNol compared to the untreated group.

Isoprostanes generated by lipid peroxidation would further aggravate neuronal cell death. The level of F2-isoprostanes (F2-IsoPs), a prominent biomarker for oxidative stress and lipid peroxidation in vivo, was also measured in all groups. The 2VO group had a significantly higher F2-IsoPs level compared to the control group. Meanwhile, EVNol-treated group (2VO+E) had significantly reduced F2-IsoPs level (5.9 ± 0.3 pg/ml) than the untreated 2VO group (16.7 ± 0.5 pg/ml).

The researchers concluded that EVNol natural full-spectrum palm tocotrienol complex could play an important role in controlling oxidative stress-induced conditions in the brain that could lead to Alzheimer’s disease. The neuroprotective effect of tocotrienols in terms of gene expression and protein expression is worthy of future study.

“The potential use of EVNol / EVNol SupraBio as neuroprotective agent has been studied for the past 20 years. That began at the Ohio State University Medical Center, led by Professor Chandan Sen. This study adds to the compelling body of science on the effectiveness of tocotrienols in neuroprotection and is in line with past research studies using EVNol / EVNol SupraBio vis a vis attenuation of white matter lesions, an independent risk factor for stroke (pre-stroke) and reducing stroke-induced injuries (post-stroke). It strengthens EVNol / EVNol SupraBio’s effectiveness in neuroprotection and for brain health,” says Diyanah Roslan, ExcelVite nutritionist.

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“The pressure of population ageing is strongly associated with the health status of people as they become older, and to date, there is no specific interventions for Alzheimer’s disease. If tocotrienols could help in conferring neuroprotective effect, this would be beneficial for the elderly of today and tomorrow,” added Bryan See, ExcelVite Regional Product Manager.


Mohamed, W. M., Sayeed, S., Saxena, A. K., & Oothuman, P. (2018). Oxidative Stress Status and Neuroprotection of Tocotrienols in Chronic Cerebral Hypoperfusion-Induced Neurodegeneration Rat Animal Model. International Journal of Nutrition, Pharmacology, Neurological Diseases, 8(2), 47.

Disclaimer: The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent any disease.


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