A new published study shows that natural full-spectrum palm tocotrienol complex inhibits the growth of VCaP cell line prostate cancer in nude mouse xenograft model in a dose-dependent manner.
In this study, male NCr immune-deficient mice, subcutaneously injected with VCaP cell line from a vertebral bone metastasis from a prostate cancer patient, were divided into three groups: a control group (saline), a low-dose group and a high-dose group. The low- and high-dose groups received 200 mg/kg and 400 mg/kg of palm tocotrienol complex (EVNol supplied by ExcelVite) respectively. The oral administration of tocotrienols was performed three times per week for eight weeks. Tumor volume was measured every alternate week by bioluminescence imaging. The mice were sacrificed after eight weeks of treatments followed by the collection of tumors, plasma and prostates samples.
It was found that tocotrienols-treated mice showed higher level of tocotrienols accumulation in prostate and tumor tissues than in plasma. When comparing to the control group, the tocotrienols-treated mice demonstrated reduced tumor sizes and tumor volumes in a dose-dependent manner.
In a separate in vitro experiment, tocotrienols inhibited the viability of VCaP cells in a dose-dependent manner when treated with different concentrations of individual delta-, gamma- and alpha-tocotrienol. Delta-tocotrienol showed strongest cytotoxicity (i.e. ability to impede tumor growth) followed by gamma- and alpha-tocotrienol. When undergoing cell cycle analysis, tocotrienols-treated mice show reduced protein expression of cyclin D1 and cyclin A (i.e. inhibition of cell proliferation), acetylation of p21 and p27 genes, as well as reduced expression of histone deacetylases (HDACs). All of which are associated with tumor growth.
“To our knowledge, this is the first study that shows full-spectrum palm tocotrienol complex inhibit prostate cancer cell growth via histone modification (i.e. specific proteins that stop cancerous cell division). Taken together, with the previous encouraging results on transgenic adenocarcinoma of the mouse prostate (TRAMP) models, EVNol may potentially be beneficial and support healthy prostate function1. It would be a great synergistic effect of natural compound with other phytonutrients such as lycopene, phytosterols and saw palmetto for promoting prostate health formula,” said ExcelVite Nutritionist.CheeYen Lau.
“EVNol is natural full spectrum tocotrienol complex (α-, β-, γ- and δ-tocotrienol), extracted through a mild molecular distillation processes, from red palm fruit oil. This patented molecular distillation process doesn’t involve any high temperature process which minimizes losses while preserving the naturalness and integrity of tocotrienols and other phytonutrients from the palm fruits,” said ExcelVite Regional Product Manager Bryan See.
- Barve A, et al. (2010). Mixed Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice. Nutr Cancer, 62(6), 789-794.
- Huang Y, et al. (2016). A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27. Journal of Nutritional Biochemistry, 40, 155-163.